Best 35 Alternative 3′ Cleavage Sites Result In

Alternative 3′ Cleavage Sites Result In

What is polyadenylation and alternative cleavage?

Alternative cleavage and polyadenylation: extent, regulation and function The 3' end of most protein-coding genes and long non-coding RNAs is cleaved and polyadenylated. Recent discoveries have revealed that a large proportion of these genes contains more than one polyadenylation site.

What is the role of cleavage factor I in 3'UTR length regulation?

Gruber AR, Martin G, Keller W, Zavolan M. Cleavage factor Im is a key regulator of 3′ UTR length. RNA Biol. 2012;9 (12):1405–12. 49. Martin G, Gruber AR, Keller W, Zavolan M. Genome-wide analysis of pre-mRNA 3′ end processing reveals a decisive role of human cleavage factor I in the regulation of 3′ UTR length.

Is cleavage Factor Im a heterotetrameric protein complex?

Kim, S. et al. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. Genes Cells 15, 1003–1013 (2010).

What is global cleavage enhancement at proximal poly (A) sites?

Global enhancement of cleavage at proximal poly (A) sites was also detected in conditions of cardiac hypertrophy, which is an enlargement of the heart that occurs in response to physiological or pathological stimuli 65. Uncontrolled cellular proliferation is a hallmark of cancer development.

Alternative 3′ Cleavage Sites Result In

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